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Construction of a 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one skeleton via a catalyst-free radical cascade addition/cyclization using azo compounds as radical sources

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Abstract

A new radical addition/cyano insertion/homolytic aromatic substitution cascade reaction initiated by the thermal homolysis of azo compounds to access polycyclic phenanthridine derivatives has been developed. Under the catalyst and oxidant free conditions, a broad range of N-arylacrylamides are compatible to afford the desired 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one derivatives in moderate to high yields.

Graphical abstract: Construction of a 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one skeleton via a catalyst-free radical cascade addition/cyclization using azo compounds as radical sources

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Publication details

The article was received on 11 Oct 2017, accepted on 19 Nov 2017 and first published on 22 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00926G
Citation: Org. Chem. Front., 2018, Advance Article
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    Construction of a 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one skeleton via a catalyst-free radical cascade addition/cyclization using azo compounds as radical sources

    C. Zhang, J. Pi, S. Chen, P. Liu and P. Sun, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00926G

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