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Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

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Abstract

The Brønsted/Lewis acid catalyzed reaction of pyrrolidone, piperidone and isoindolinone derivatives tethered to α,β-unsaturated ketones or aldehydes afforded exclusively polyfunctionalized 1,3-oxazines with high diastereoselectivities and in high yields.

Graphical abstract: Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

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Publication details

The article was received on 29 Sep 2017, accepted on 25 Oct 2017 and first published on 26 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00891K
Citation: Org. Chem. Front., 2018, Advance Article
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    Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

    C. Peter, P. Geoffroy and M. Miesch, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00891K

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