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Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

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Abstract

An enantioselective C–H functionalization of pyrrole derivatives with diazo compounds has been successfully realized with up to 90% ee by employing dichlorobis(benzonitrile)palladium with an axially chiral bipyridine ligand C3-ACBP as the catalyst. Asymmetric C–H functionalization at the gram scale was also conducted smoothly with good reactivity and enantioselectivity.

Graphical abstract: Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

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Publication details

The article was received on 09 Sep 2017, accepted on 03 Nov 2017 and first published on 06 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00815E
Citation: Org. Chem. Front., 2018, Advance Article
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    Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

    H. Shen, C. Liu, J. Zhou and Y. Zhou, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00815E

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