Issue 4, 2018

Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

Abstract

An enantioselective C–H functionalization of pyrrole derivatives with diazo compounds has been successfully realized with up to 90% ee by employing dichlorobis(benzonitrile)palladium with an axially chiral bipyridine ligand C3-ACBP as the catalyst. Asymmetric C–H functionalization at the gram scale was also conducted smoothly with good reactivity and enantioselectivity.

Graphical abstract: Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

Supplementary files

Article information

Article type
Research Article
Submitted
09 Sep 2017
Accepted
03 Nov 2017
First published
06 Nov 2017

Org. Chem. Front., 2018,5, 611-614

Enantioselective palladium-catalyzed C–H functionalization of pyrroles using an axially chiral 2,2′-bipyridine ligand

H. Shen, C. Liu, J. Zhou and Y. Zhou, Org. Chem. Front., 2018, 5, 611 DOI: 10.1039/C7QO00815E

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