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Photoredox 1,2-dicarbofunctionalization of unactivated alkenes via tandem radical difluoroalkylation and alkynyl migration

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Abstract

Visible-light-mediated tandem radical difluoroalkylation and alkynylation of unactivated alkenes is described in this communication. The process comprises a mild C–C bond activation via intramolecular 1,4-alkynyl migration. The general and elegant protocol can serve as a straightforward access route to obtain a wide range of synthetically valuable difluoroalkylated linear alkynyl ketones under mild reaction conditions.

Graphical abstract: Photoredox 1,2-dicarbofunctionalization of unactivated alkenes via tandem radical difluoroalkylation and alkynyl migration

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Publication details

The article was received on 07 Sep 2017, accepted on 03 Nov 2017 and first published on 06 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00808B
Citation: Org. Chem. Front., 2018, Advance Article
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    Photoredox 1,2-dicarbofunctionalization of unactivated alkenes via tandem radical difluoroalkylation and alkynyl migration

    J. Liu, W. Li, J. Xie and C. Zhu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00808B

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