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Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

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Abstract

A practical photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation is described herein, with dihydrogen as the only by-product. A variety of lactone products can be successfully constructed under oxidant- and acceptor-free conditions with good functional group tolerance and high yield. This protocol also provides a facile route to remote hydroxylated arenes and chromene.

Graphical abstract: Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

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Publication details

The article was received on 04 Sep 2017, accepted on 06 Nov 2017 and first published on 07 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00795G
Citation: Org. Chem. Front., 2018, Advance Article
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    Photoredox and cobalt co-catalyzed C(sp2)–H functionalization/C–O bond formation for synthesis of lactones under oxidant- and acceptor-free conditions

    M. Zhang, R. Ruzi, N. Li, J. Xie and C. Zhu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00795G

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