Copper-catalysed dehydrogenative α-C(sp3)–H amination of tetrahydroquinolines with O-benzoyl hydroxylamines

He Zhao; Xiuwen Chen; Huanfeng Jiang; Min Zhang

doi:10.1039/C7QO00794A

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Copper-catalysed dehydrogenative α-C(sp³)–H amination of tetrahydroquinolines with O-benzoyl hydroxylamines†

He Zhao,^a Xiuwen Chen,^a Huanfeng Jiang

^a and Min Zhang

*^a

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* Corresponding authors

^a Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: minzhang@scut.edu.cn

Abstract

A copper-catalysed dehydrogenative α-C(sp³)–H amination of tetrahydroquinolines with O-benzoyl hydroxylamines has been demonstrated for the first time, which proceeds with the merits of operational simplicity, good functional tolerance, mild conditions, the use of O₂ as the oxidant and no need for the installation of directing groups.

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Article information

DOI: https://doi.org/10.1039/C7QO00794A
Article type: Research Article
Submitted: 04 Sep 2017
Accepted: 11 Oct 2017
First published: 12 Oct 2017

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Org. Chem. Front., 2018,5, 539-543

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Copper-catalysed dehydrogenative α-C(sp³)–H amination of tetrahydroquinolines with O-benzoyl hydroxylamines

H. Zhao, X. Chen, H. Jiang and M. Zhang, Org. Chem. Front., 2018, 5, 539 DOI: 10.1039/C7QO00794A

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