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Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

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Abstract

Two synthetic routes have been developed for the asymmetric synthesis of tetrahydroprotoberberines, featuring installation of the asymmetry at an early stage of asymmetric redox-A3 reaction and the late stage of asymmetric Noyori asymmetric transfer hydrogenation, respectively. This work is filling the gap between racemic and asymmetric syntheses of tetrahydroprotoberberines enabled by redox-A3 reaction.

Graphical abstract: Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

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Publication details

The article was received on 30 Aug 2017, accepted on 30 Sep 2017 and first published on 09 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00776K
Citation: Org. Chem. Front., 2018, Advance Article
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    Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

    J. Yu, Z. Zhang, S. Zhou, W. Zhang and R. Tong, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00776K

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