Issue 2, 2018

Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

Abstract

Two synthetic routes have been developed for the asymmetric synthesis of tetrahydroprotoberberines, featuring installation of the asymmetry at an early stage of asymmetric redox-A3 reaction and the late stage of asymmetric Noyori asymmetric transfer hydrogenation, respectively. This work is filling the gap between racemic and asymmetric syntheses of tetrahydroprotoberberines enabled by redox-A3 reaction.

Graphical abstract: Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

Supplementary files

Article information

Article type
Research Article
Submitted
30 Aug 2017
Accepted
30 Sep 2017
First published
09 Oct 2017

Org. Chem. Front., 2018,5, 242-246

Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids

J. Yu, Z. Zhang, S. Zhou, W. Zhang and R. Tong, Org. Chem. Front., 2018, 5, 242 DOI: 10.1039/C7QO00776K

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