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Issue 7, 2018
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A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions

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Abstract

4-(2-Substituted-[1,3]thiazolo[3,2-a]benzimidazol-3-yl)quinazolin-2-amines were prepared by the multi-component reaction of 2,4-dichloroquinazoline, terminal alkynes, secondary amines, and 1H-benzo[d]imidazole-2(3H)-thione in the presence of a palladium–copper catalyst. This one-pot process provided an efficient and successful approach for the synthesis of a new thiazolo[3,2-a]benzimidazole linked-quinazoline scaffold with good to high yields.

Graphical abstract: A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions

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Publication details

The article was received on 23 Aug 2017, accepted on 06 Jan 2018 and first published on 09 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO00751E
Citation: Org. Chem. Front., 2018,5, 1135-1142
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    A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions

    A. Keivanloo, A. Soozani, M. Bakherad and A. H. Amin, Org. Chem. Front., 2018, 5, 1135
    DOI: 10.1039/C7QO00751E

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