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Regioselective C5 alkenylation of 2-acylpyrroles via Pd(II)-catalyzed C–H bond activation

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Abstract

A Pd(II)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles has been developed employing 3-nitrile benzoyl group (N-(3-NCC6H4CO-)) as an efficient N-protecting group. The protocol provided a simple and efficient method to synthesize C5-alkenylated 2-acylpyrrole derivatives. The employed N-protecting group was readily removable in the presence of HCl/EtOH under mild conditions.

Graphical abstract: Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation

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Publication details

The article was received on 17 Aug 2017, accepted on 30 Sep 2017 and first published on 09 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00732A
Citation: Org. Chem. Front., 2018, Advance Article
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    Regioselective C5 alkenylation of 2-acylpyrroles via Pd(II)-catalyzed C–H bond activation

    J. Duan, R. Mi, J. Sun and M. Zhou, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00732A

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