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Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

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Abstract

A scandium complex based on a new type of tridentate ligand enabled an atom- and step-economical C(sp3)–H addition of N,N-dimethyl anilines to a variety of unactivated alkenes affording branched products for the first time. A cationic o-dimethylaminophenyl scandium species was isolated and confirmed as the catalytic intermediate in this transformation.

Graphical abstract: Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

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Publication details

The article was received on 14 Aug 2017, accepted on 19 Sep 2017 and first published on 20 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00718C
Citation: Org. Chem. Front., 2018, Advance Article
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    Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

    H. Gao, J. Su, P. Xu and X. Xu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00718C

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