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Catalytic asymmetric synthesis of pyrrolidine derivatives bearing heteroatom-substituted quaternary stereocenters

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Abstract

An enantioselective [3 + 2] cycloaddition of heteroatom-substituted alkenes with α-substituted isocyanoacetates has been developed. The resulting cycloadducts could be further transformed to access a number of structurally diverse and biologically important pyrrolidine derivatives which bear sulfur- or oxygen-substituted quaternary stereocenters. Excellent reactivity and enantioselectivity were obtained for a broad range of substrates.

Graphical abstract: Catalytic asymmetric synthesis of pyrrolidine derivatives bearing heteroatom-substituted quaternary stereocenters

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Publication details

The article was received on 04 Aug 2017, accepted on 17 Sep 2017 and first published on 18 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00692F
Citation: Org. Chem. Front., 2018, Advance Article
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    Catalytic asymmetric synthesis of pyrrolidine derivatives bearing heteroatom-substituted quaternary stereocenters

    Z. Wang, Q. Wu, J. Jiang, Z. Li, X. Peng, P. Shao and Y. He, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00692F

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