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Radical-mediated synthesis of γ-lactones by copper-catalyzed intermolecular carboesterification of alkenes with α-carbonyl alkyl bromides and H2O

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Abstract

A novel copper-catalyzed intermolecular carboesterification strategy of alkenes with α-carbonyl alkyl bromides is described. This reaction represents a facile and straightforward access to polysubstituted γ-lactone skeletons, including γ-lactones having ortho-substituted groups on the carbonyl group, in moderate to good yields via a radical strategy, which has good functional group tolerance.

Graphical abstract: Radical-mediated synthesis of γ-lactones by copper-catalyzed intermolecular carboesterification of alkenes with α-carbonyl alkyl bromides and H2O

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Publication details

The article was received on 13 Jul 2017, accepted on 17 Sep 2017 and first published on 20 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00579B
Citation: Org. Chem. Front., 2018, Advance Article
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    Radical-mediated synthesis of γ-lactones by copper-catalyzed intermolecular carboesterification of alkenes with α-carbonyl alkyl bromides and H2O

    G. Pan, R. Song and J. Li, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00579B

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