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Thermo-responsive phase-transition polymer grafted magnetic FePt nanoparticles with tunable critical temperature for controlled drug release

Abstract

A temperature stimuli-responsive drug release system is presented in this work. Polymer (poly(N-isopropylacrylamide), PNIPAM based polymer) grafted FePt nanocluster was fabricated, tethered with folic acid (FA) on its surface for cancer-cell specific targeting. The reversible thermal response of the prepared nanocluster has been successfully verified, and the threshold temperature for drug release is tunable as the lower critical solution temperature (LCST) of the polymer could be modulated from 32 to 45 C by adjusting comonomers and their relative composition ratios. The resultant nanocluster realized both amphipathic and hydrophobic cargo release resulting from the shrinkage of the polymer responding to temperature rise. Fluorescence spectroscopic analysis indicates that amphipathic molecules can be released out of the nanocluster more efficiently than hydrophobic ones. Additionally, superparamagnetic FePt NPs have the potential to serve as the heat source of the system through magnetocaloric effect. And the nanocluster can respond to pH as well, which holds promise for therapy of various issues with different pH values. With excellent cytocompatibility and flexible composition design, this thermal responsive nanocluster has a great prospect for controlled drug release to address series of clinical indications.

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Publication details

The article was received on 08 Apr 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Research Article
DOI: 10.1039/C8QM00154E
Citation: Mater. Chem. Front., 2018, Accepted Manuscript
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    Thermo-responsive phase-transition polymer grafted magnetic FePt nanoparticles with tunable critical temperature for controlled drug release

    Z. Kang, Y. Peng, L. Zhou, Z. Li, T. Wang, Z. Zhang, Q. Liao, J. Gao, Y. Li and Y. Zhang, Mater. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QM00154E

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