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Design and preparation of quasi-spherical salt particles as water-soluble porogens to fabricate hydrophobic porous scaffolds for tissue engineering and tissue regeneration

Abstract

Design and preparation of appropriate porogens are critical in fabrication of porous scaffolds for tissue engineering and tissue regeneration. Our analysis based on the percolation theroy reveals that a spherical porogen is better than a cubic porogen. Nevertheless, while porous scaffolds with spherical interior pores have exhibited advantages over those of cubic pores, salt as the most popular and convenient porogen can only be shaped cubically due to the principle of crystallography. Hererin, we propose a strategy to prepare, indirectly, quasi-spherical salt macroparticles simply via gluing small salt particles by sugar melt. The popular biodegradable polymer poly(D,L-lactide-co-glycolide) (PLGA) was employed as the hydrophobic matrix, and the polymeric scaffolds with quasi-spherical pores were successfully fabricated by room-temperature compression molding and particulate leaching. Compared to PLGA scaffolds fabricated by conventional cubic salt macroparticles, our improved scaffolds exhibited excellent pore interconnectivity and fewer porogen residues. Two additional advantages of the new fabrication approach were also found: one is quicker porogen leaching by water in fabrication of PLGA scaffolds, which might be owing to easier water penetration into the intervals of those microparticles; the other is favourable cell adhesion and osteogenic differentiation on the pore wall, which might be attributed to the roughness of the interior surfaces templated from the porogen surfaces composed of many microparticles. The new approach and resultant scaffolds are promising in regenerative medicine.

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Publication details

The article was received on 06 Apr 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QM00152A
Citation: Mater. Chem. Front., 2018, Accepted Manuscript
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    Design and preparation of quasi-spherical salt particles as water-soluble porogens to fabricate hydrophobic porous scaffolds for tissue engineering and tissue regeneration

    X. Liang, Y. Qi, Z. Pan, Y. He, X. Liu, S. Cui and J. Ding, Mater. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QM00152A

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