Jump to main content
Jump to site search

Issue 5, 2018
Previous Article Next Article

The renaissance of nitric oxide: from improvement of stability to enhancement of endocytosis

Author affiliations

Abstract

In this perspective article, we have reviewed the exploration of nitric oxide (NO) over the past 40 years and tried to catch a glimpse of the possible future direction of NO research. A lot of astounding achievements have already been made, from the discovery of the physiological mechanism of NO to the fabrication of a feasible NO delivery system. However, a large portion of NO action sites are inside cells, and indiscriminate distribution of NO donors would undoubtedly bring about a mismatch between the NO release and action sites. These mispairings not only reduce the efficacy of NO applications, but also cause undesirable side effects. Based on these arguments, we propose that the local generation and intracellular release of NO is no less vital than improving the stability of the carriers. Potential solutions to this problem have also been put forward. We hope our views and concepts will prove helpful to inspire new ideas for NO applications.

Graphical abstract: The renaissance of nitric oxide: from improvement of stability to enhancement of endocytosis

Back to tab navigation

Publication details

The article was received on 12 Feb 2018, accepted on 09 Mar 2018 and first published on 12 Mar 2018


Article type: Chemistry Frontiers
DOI: 10.1039/C8QM00013A
Citation: Mater. Chem. Front., 2018,2, 830-834
  •   Request permissions

    The renaissance of nitric oxide: from improvement of stability to enhancement of endocytosis

    F. Jia, Y. Deng and J. Ji, Mater. Chem. Front., 2018, 2, 830
    DOI: 10.1039/C8QM00013A

Search articles by author

Spotlight

Advertisements