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Highly selective electrochemical detection of antipsychotic drug chlorpromazine in drug and human urine samples based on peas-like strontium molybdate as a electrocatalyst

Abstract

The countless use of antibiotics in veterinary and human medicine causes serious health risk to the both human and animals. In this context, monitoring of the antibiotic drug in the veterinary and human pathological system is an important and provokes a universal challenge. Therefore, development of simple and sensitive inorganic materials with unique morphology is great importance for the trace level monitoring of pharmaceuticals content in the environment. Herein, we developed a novel peas-like strontium molybdate catalyst (SrMoO4; SrM) synthesized by simple sonochemical approach and utilized as an electrochemical sensor for the detection of antipsychotic drug chlorpromazine (CPZ). The crystalline structure, surface morphology, elemental compositions and textural properties were systematically investigated by various analytical and spectroscopic techniques. As an electrochemical sensor, inorganic binary SrM modified screen printed carbon electrode (SrM/SPCE) exhibited an enhanced electrocatalytic activity towards CPZ sensing with excellent analytical performance such as wide linear response ranges and lowest detection limit of 0.1-143; 153 -1683 µM and 0.028 µM, respectively. Moreover, as-prepared SrM/SPCE showed an excellent selectivity even in the existence of co-interfering drugs, biological compounds and common metal ions. Besides, the SrM/SPCE applied to the real samples analysis in commercially available CPZ drug and human urine samples and the observed recoveries are quite satisfactory.

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Publication details

The article was received on 23 Nov 2017, accepted on 06 Jan 2018 and first published on 09 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QI00743D
Citation: Inorg. Chem. Front., 2018, Accepted Manuscript
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    Highly selective electrochemical detection of antipsychotic drug chlorpromazine in drug and human urine samples based on peas-like strontium molybdate as a electrocatalyst

    J. Vinoth Kumar, K. Raj, S. Chen, T. Kokulnathan, S. sakthinathan, V. Muthuraj, T. Chiu and T. Chen, Inorg. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C7QI00743D

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