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Trace level electrochemical determination of neurotransmitter dopamine in biological samples based on iron oxide nanoparticles decorated graphene sheets

Abstract

In this paper, we report a highly selective and sensitive electrochemical determination of dopamine (DA) based on iron oxide nanoparticles (Fe2O3 NPs) capped graphene sheets (GRS) modified glassy carbon electrode (GCE). The Fe2O3 NPs was synthesized by pyrophoric technique and its nanocomposite with GRS was prepared by the simple sonochemical method. The as-prepared Fe2O3 NPs/GRS nanocomposite was characterized by using scanning electron microscopy, electron dispersive X-ray spectroscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and electrochemical impedance spectroscopy. As expected, the proposed sensor exhibits a wide linear range from 0.01-195.18, low detection limit (LOD) of 0.004 µM for DPV technique and a broad linear range from 0.006 to 635 µM, the very low detection limit of 0.001 µM for amperometric technique, respectively. Moreover, it shows excellent selectivity of DA even in the presence of 20-fold higher concentration of potential interferences. The practical applicability of the reported sensor was recorded in human serum and urine sample. Finally, all electrochemical studies confirmed the excellent electrocatalytic activity of Fe2O3 NPs/GRS nanocomposite as a DA sensor.

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Publication details

The article was received on 15 Nov 2017, accepted on 08 Jan 2018 and first published on 08 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QI00716G
Citation: Inorg. Chem. Front., 2018, Accepted Manuscript
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    Trace level electrochemical determination of neurotransmitter dopamine in biological samples based on iron oxide nanoparticles decorated graphene sheets

    T. Kokulnathan, A. J. A, S. Chen, V. Chinnuswamy and K. Kadirvelu, Inorg. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C7QI00716G

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