Jump to main content
Jump to site search


Chiral metal–organic frameworks constructed from four-fold helical chain SBUs for enantioselective recognition of α-hydroxy/amino acids

Author affiliations

Abstract

The chiral recognition of racemic α-hydroxy/amino acids is an essential and challenging mission because enantiomers may profoundly differ in biological function, pharmacology and toxicity. Three stable, chiral 3D metal–carboxylate frameworks, namely [M2(bptc)(H2O)(MeOH)]·3H2O (bptc4− = 3,3′,5,5′-biphenyltetracarboxylate, M = Co, CoNi for 1–2, and [Ni2(bptc)(MeOH)2]·3H2O for 3) have been successfully obtained by spontaneous resolution with an achiral ligand H4bptc, and they crystallize in the chiral tetragonal space group I4122, and feature chiral four-fold helical metal chains as SBUs. In particular, the Co-MOF material could be used to rapidly and sensitively recognize racemic α-hydroxy/amino acids by the intensity change of circular dichroism signals. A large relative difference of 38.59% in circular dichroism signals for D/L-mandelic acid is achieved, which may be ascribed to the specific recognition sites (i.e., groove of helical chains) and different bonding energies of D/L-isomers in the chiral microenvironment of the crystal structure.

Graphical abstract: Chiral metal–organic frameworks constructed from four-fold helical chain SBUs for enantioselective recognition of α-hydroxy/amino acids

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Oct 2017, accepted on 08 Nov 2017 and first published on 24 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QI00615B
Citation: Inorg. Chem. Front., 2018, Advance Article
  •   Request permissions

    Chiral metal–organic frameworks constructed from four-fold helical chain SBUs for enantioselective recognition of α-hydroxy/amino acids

    R. Yao, H. Fu, B. Yu and X. Zhang, Inorg. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QI00615B

Search articles by author

Spotlight

Advertisements