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Issue 2, 2018
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Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

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Abstract

Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60–100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg−1 and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.

Graphical abstract: Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

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Publication details

The article was received on 17 Sep 2017, accepted on 15 Dec 2017 and first published on 18 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QI00575J
Citation: Inorg. Chem. Front., 2018,5, 474-480
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    Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

    D. Wang, C. Zhang, L. Ren, D. Li and J. Yu, Inorg. Chem. Front., 2018, 5, 474
    DOI: 10.1039/C7QI00575J

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