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Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

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Abstract

Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.

Graphical abstract: Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

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Publication details

The article was received on 28 Jul 2017, accepted on 16 Oct 2017 and first published on 18 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QI00446J
Citation: Inorg. Chem. Front., 2018, Advance Article
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    Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

    A. I. Matesanz, E. Jimenez-Faraco, M. C. Ruiz, L. M. Balsa, C. Navarro-Ranninger, I. E. León and A. G. Quiroga, Inorg. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QI00446J

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