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Issue 25, 2018
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Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

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Abstract

Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.

Graphical abstract: Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

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Publication details

The article was received on 08 May 2018, accepted on 07 Jun 2018 and first published on 08 Jun 2018


Article type: Communication
DOI: 10.1039/C8PY00703A
Citation: Polym. Chem., 2018,9, 3461-3465
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    Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

    M. Müllner, K. Yang, A. Kaur and E. J. New, Polym. Chem., 2018, 9, 3461
    DOI: 10.1039/C8PY00703A

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