Jump to main content
Jump to site search


Elaboration of antimicrobial polymeric materials by dispersion of well-defined amphiphilic methacrylic SG1-based copolymers

Abstract

The bacterial resistance to antibiotics is a major public health problem and it is urgent to find new antimicrobial materials to circumvent the development of resistant pathogens. The aim of this work is to propose an efficient and versatile method of elaboration of antimicrobial polymeric materials based on the simple dispersion of a low amount of high molecular weight (Mn > 20,000 g.mol-1) amphiphilic methacrylic copolymers prepared by nitroxide-mediated polymerization in different common organic matrices (here PS and PMMA). More precisely, after studying the influence of different copolymer parameters on their biological activity (the amount and type of comonomer (styrene or acrylonitrile), the architecture (random or diblock), and the type of cationic charge (permanent or not), some selected candidates were dispersed in PS and PMMA matrices and proved to efficiently turn these inactive materials into antibacterial ones without a significant hemolytic character. In particular, only 0.02 wt% of antimicrobial copolymers were sufficient to confer an activity against both Gram positive (B. subtilis) and Gram negative (E. coli) bacteria.

Back to tab navigation

Publication details

The article was received on 05 Apr 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8PY00523K
Citation: Polym. Chem., 2018, Accepted Manuscript
  •   Request permissions

    Elaboration of antimicrobial polymeric materials by dispersion of well-defined amphiphilic methacrylic SG1-based copolymers

    T. Benkhaled, S. Hadiouch, H. Olleik, J. Perrier, C. Ysacco, D. Gigmes, Y. Guillaneuf, M. Maresca and C. Lefay, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8PY00523K

Search articles by author

Spotlight

Advertisements