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Issue 21, 2018
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In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly

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Abstract

Frequently, the classical self-assembly techniques applied to amphiphilic glycopolymers lead to primitive morphologies, i.e. spherical micelles/nanoparticles. Herein, we report a facile and rapid one-pot synthesis and self-assembly of grafted amphiphilic glycopolymers using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA) under UV-irradiation at room temperature. Such glycopolymers were based on dextran as a hydrophilic steric stabilizer backbone and poly(hydroxypropyl methacrylate) PHPMA as a hydrophobic graft. Transmission electron microscopy and light scattering analysis reveal the formation of a broad set of advanced glyco-nanostructures ranging from spherical micelles to worm-like micelles and vesicles depending on both the PHPMA graft length and the solids content.

Graphical abstract: In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly

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Publication details

The article was received on 28 Feb 2018, accepted on 15 Apr 2018 and first published on 16 Apr 2018


Article type: Communication
DOI: 10.1039/C8PY00346G
Citation: Polym. Chem., 2018,9, 2868-2872
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    In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly

    K. Ferji, P. Venturini, F. Cleymand, C. Chassenieux and J. Six, Polym. Chem., 2018, 9, 2868
    DOI: 10.1039/C8PY00346G

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