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Issue 17, 2018
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High-performance cationic polyrotaxanes terminated with polypeptides as promising nucleic acid delivery systems

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Abstract

Nucleic acid (NA)-based therapy was put forward as a promising method to conquer serious human diseases. Safe and robust gene vectors play an important role in NA delivery processes. In this work, a novel ABA-triblock hydroxyl-rich cationic polyrotaxane PP-PGEA, consisting of one polyethylene glycol backbone, CD-PGEA (composed of one cyclodextrin (CD) core and three ethanolamine (EA)-functionalized poly(glycidyl methacrylate) arms) assembly units, and degradable end-capping polypeptide segments, was prepared as a promising NA delivery system. PP-PGEA has low cytotoxicity and degradability, beneficial to the NA delivery process. The breakdown of end-capping polypeptides could benefit the disassembly of PP-PGEA within cells. PP-PGEA demonstrated substantially higher transfection performances than CD-PGEA assembly units. PP-PGEA was also shown to possess remarkable anti-cancer capability through glioma models. Such a high-performance cationic polyrotaxane with terminal polypeptides would provide a very promising means to produce efficient delivery vectors of versatile NAs.

Graphical abstract: High-performance cationic polyrotaxanes terminated with polypeptides as promising nucleic acid delivery systems

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Publication details

The article was received on 27 Feb 2018, accepted on 01 Apr 2018 and first published on 02 Apr 2018


Article type: Paper
DOI: 10.1039/C8PY00333E
Citation: Polym. Chem., 2018,9, 2281-2289
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    High-performance cationic polyrotaxanes terminated with polypeptides as promising nucleic acid delivery systems

    H. Song, Y. Qi, R. Li, G. Cheng, N. Zhao and F. Xu, Polym. Chem., 2018, 9, 2281
    DOI: 10.1039/C8PY00333E

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