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Color-tunable AIE-active Conjugated Polymer Nanoparticles as Drug Carrier for Self-indicated Cancer Therapy via Intramolecular FRET Mechanism

Abstract

In this paper, two novel AIE-active conjugated polymers were synthesized by Pd-catalyzed Suzuki coupling polymerization reaction. Interestingly, the obtained conjugated polymers can exhibit obvious color-tunable AIE behavior by adjusting their intramolecular FRET pairs. Among them, P-1 with only one intramolecular FRET pair exhibits obvious green-colored AIE fluorescence. As the second intramolecular FRET pair from TPE moiety to DTBT moiety added (P-2), the AIE fluorescence color can be tuned from green to red. The Stokes shift can also sharply increase from 125 nm to 255 nm. Furthermore, these AIE-active polymers can form the stable conjugated polymer nanoparticles (CPNs) in aqueous system and act as drug carriers for paclitaxel (PTX). Most importantly, the carried PTX can be sufficiently released from this AIE-active CPNs and show effective cytotoxicity on HeLa and A549 cells. Especially, these two AIE-active drug carriers can not only be internalized by cells, but also reveal the location with green or red colored AIE fluorescence. This work can provide a novel strategy for designing color-tunable AIE-active CPNs based drug carriers for self-indicated cancer therapy via changing intramolecular FRET pairs.

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Publication details

The article was received on 26 Feb 2018, accepted on 13 Apr 2018 and first published on 14 Apr 2018


Article type: Paper
DOI: 10.1039/C8PY00329G
Citation: Polym. Chem., 2018, Accepted Manuscript
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    Color-tunable AIE-active Conjugated Polymer Nanoparticles as Drug Carrier for Self-indicated Cancer Therapy via Intramolecular FRET Mechanism

    Z. Wang, C. Wang, Y. Fang, H. Yuan, Q. Yiwu and Y. Cheng, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8PY00329G

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