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An L-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

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Abstract

The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N′-methylenebis(acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43 °C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43 °C, thus confirming the dual stimuli switch.

Graphical abstract: An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

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Publication details

The article was received on 22 Feb 2018, accepted on 24 Mar 2018 and first published on 09 Apr 2018


Article type: Paper
DOI: 10.1039/C8PY00308D
Citation: Polym. Chem., 2018, Advance Article
  • Open access: Creative Commons BY license
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    An L-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

    Y. Salinas, A. M. Castilla and M. Resmini, Polym. Chem., 2018, Advance Article , DOI: 10.1039/C8PY00308D

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