Jump to main content
Jump to site search

Issue 15, 2018
Previous Article Next Article

High-throughput physicochemical analysis of thermoresponsive polymers

Author affiliations

Abstract

Calculating the lower critical solution temperature (LCST) of a thermoresponsive polymer is an important measure of its physical properties. Here, the LCST of poly(N-isopropylacrylamide) (pNIPAM) was determined by measuring the scattered light intensity in a real-time thermocycler. This method allowed for the investigation of low concentration (μg mL−1) samples in low volumes (μL). Subsequently, the critical micelle temperatures (CMTs) and concentrations (CMCs) were simultaneously recorded in 2 h for over 220 samples of the thermoresponsive copolymers of NIPAM with N-hydroxymethyl acrylamide (HMAM) (pNIPAM-co-HMAM (2.5–12.5 mol% HMAM)). This high-throughput approach paves the way to rapidly ‘map’ the physicochemical properties of low abundance polymers with statistical accuracy.

Graphical abstract: High-throughput physicochemical analysis of thermoresponsive polymers

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Dec 2017, accepted on 06 Feb 2018 and first published on 07 Feb 2018


Article type: Communication
DOI: 10.1039/C7PY02066J
Citation: Polym. Chem., 2018,9, 1934-1937
  •   Request permissions

    High-throughput physicochemical analysis of thermoresponsive polymers

    S. J. M. C. Bou, A. R. Connolly and A. V. Ellis, Polym. Chem., 2018, 9, 1934
    DOI: 10.1039/C7PY02066J

Search articles by author

Spotlight

Advertisements