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Amino acid-derived stimuli-responsive polymers and their applications

Abstract

Natural biopolymers such as proteins and nucleic acids in living organisms possess inherent ability to respond to local environmental stimuli, which motivated the researchers to make biomolecules-derived non-biological macromolecules with biomimetic structure having stimuli-responsive properties. This review mainly focuses on stimuli-responsive polymers having natural amino acid units either in the main-chain or in the side-chain, their self-assembled nanostructures and hydrogel networks. Recent advances in the design and synthesis of amino acid-derived polymers that are responsive to various physical, chemical, or biochemical stimuli such as temperature, light, pH, redox-, metal ions, gas, glucose, enzyme, proteins, DNA or combination of these are illustrated. Their potentials as stimuli-responsive “smart” nanomaterials in biomedical and biotechnological applications such as in controlled drug delivery, gene delivery, non-fouling materials, etc. are also highlighted. The primary aim of this review article is to motivate researchers towards design and synthesis of novel stimuli-responsive biohybrid materials for making next generation smart materials.

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Publication details

The article was received on 01 Dec 2017, accepted on 30 Jan 2018 and first published on 30 Jan 2018


Article type: Review Article
DOI: 10.1039/C7PY02014G
Citation: Polym. Chem., 2018, Accepted Manuscript
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    Amino acid-derived stimuli-responsive polymers and their applications

    K. Bauri, M. Nandi and P. De, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7PY02014G

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