Issue 9, 2018

Self-assembly of random co-polymers for selective binding and detection of peptides

Abstract

Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been designed and synthesized. We demonstrate that the reverse micelles, formed by these co-polymers are capable of selectively binding peptides through electrostatic interactions, indicating that these random polymers can self-organize into functionally selective materials. Moreover, these random co-polymers also enable the ordered co-crystallization of matrix and extract guest molecules, giving rise to substantial signal enhancements during MALDI-MS detection. Together, these observations represent an excellent example of how random polymers can self-assemble into ordered, functional materials.

Graphical abstract: Self-assembly of random co-polymers for selective binding and detection of peptides

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2017
Accepted
18 Dec 2017
First published
19 Dec 2017

Polym. Chem., 2018,9, 1066-1071

Self-assembly of random co-polymers for selective binding and detection of peptides

B. Zhao, M. A. C. Serrano, J. Gao, J. Zhuang, R. W. Vachet and S. Thayumanavan, Polym. Chem., 2018, 9, 1066 DOI: 10.1039/C7PY01947E

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