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Issue 9, 2018
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Self-assembly of random co-polymers for selective binding and detection of peptides

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Abstract

Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been designed and synthesized. We demonstrate that the reverse micelles, formed by these co-polymers are capable of selectively binding peptides through electrostatic interactions, indicating that these random polymers can self-organize into functionally selective materials. Moreover, these random co-polymers also enable the ordered co-crystallization of matrix and extract guest molecules, giving rise to substantial signal enhancements during MALDI-MS detection. Together, these observations represent an excellent example of how random polymers can self-assemble into ordered, functional materials.

Graphical abstract: Self-assembly of random co-polymers for selective binding and detection of peptides

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Publication details

The article was received on 20 Nov 2017, accepted on 18 Dec 2017 and first published on 19 Dec 2017


Article type: Paper
DOI: 10.1039/C7PY01947E
Citation: Polym. Chem., 2018,9, 1066-1071
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    Self-assembly of random co-polymers for selective binding and detection of peptides

    B. Zhao, M. A. C. Serrano, J. Gao, J. Zhuang, R. W. Vachet and S. Thayumanavan, Polym. Chem., 2018, 9, 1066
    DOI: 10.1039/C7PY01947E

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