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Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

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Abstract

We pioneer an approach for the visualization of pH-controlled molecular release of a fluorescent drug from a nitroxide polymer which combined yields a profluorescent system. A methacrylate-based terpolymer, bearing water-solubilizing triethylene-glycol chains, unpaired spins in the form of nitroxide and hydrazone-bound doxorubicin was synthesized to explore the possibilities of release quantification from profluorescent assemblies. Critically, we establish the fluorescence-silencing effect of polymer-bound nitroxides on covalently attached fluorophores and the overall accessibility of such constructs. The facile approach towards a functional assembly shown here provides an easy-to-assemble construct for complex delivery architectures towards applications in theranostics.

Graphical abstract: Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

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Publication details

The article was received on 20 Nov 2017, accepted on 20 Dec 2017 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7PY01942D
Citation: Polym. Chem., 2018, Advance Article
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    Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

    M. Eing, B. Olshausen, K. E. Fairfull-Smith, U. Schepers, C. Barner-Kowollik and J. P. Blinco, Polym. Chem., 2018, Advance Article , DOI: 10.1039/C7PY01942D

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