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Metal assisted self-assembled rod like nanostructures for effective cellular internalization

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Abstract

Well-designed polymeric self-assembled materials are in high demand because of the need for better alternatives to the conventional system. A nano-structure that is self-assembled, driven by different forces related to synthetic polymers follows different uptake kinetics at the cellular level. Herein we designed a norbornene-functionalized amphiphilic homopolymer that represents a unique self-assembled nanostructure in polar solvent. The self-assembled nanoaggregates were scrutinized using dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. The vesicular nanoaggregates of the homopolymer changed their shape to nanorods in the presence of Fe(II) in polar medium. The self-assembled nanorods we reutilized for doxorubicin loading showed a higher uptake than the vesicular structures loaded with the drug in the absence of Fe(II). This simple strategy of preparing nanorods can be helpful for future application in the field of drug delivery.

Graphical abstract: Metal assisted self-assembled rod like nanostructures for effective cellular internalization

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Publication details

The article was received on 10 Nov 2017, accepted on 22 Feb 2018 and first published on 22 Feb 2018


Article type: Paper
DOI: 10.1039/C7PY01893B
Citation: Polym. Chem., 2018, Advance Article
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    Metal assisted self-assembled rod like nanostructures for effective cellular internalization

    S. Bhattacharya, S. Mukherjee, J. Das Sarma and R. Shunmugam, Polym. Chem., 2018, Advance Article , DOI: 10.1039/C7PY01893B

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