Jump to main content
Jump to site search

Issue 3, 2018
Previous Article Next Article

Entry of nanoparticles into cells: the importance of nanoparticle properties

Author affiliations

Abstract

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great importance for the design of safe and efficient nanomedicines. Extensive studies aimed at understanding the correlation of NP properties with endocytosis have been carried out in the past few years. Here, we review the recent progress of these studies and provide an overview of the current state of knowledge on the influence of NP size, shape, stiffness and surface chemistry on cellular uptake. Special attention was dedicated to the uptake of non-spherical nanoparticles. Some general principles obtained from these fundamental studies will serve as guidelines for the design of optimised NP for enhanced cellular uptake. Finally, the opportunities for polymer chemists are discussed.

Graphical abstract: Entry of nanoparticles into cells: the importance of nanoparticle properties

Back to tab navigation

Publication details

The article was received on 18 Sep 2017, accepted on 18 Dec 2017 and first published on 18 Dec 2017


Article type: Review Article
DOI: 10.1039/C7PY01603D
Citation: Polym. Chem., 2018,9, 259-272
  •   Request permissions

    Entry of nanoparticles into cells: the importance of nanoparticle properties

    J. Zhao and M. H. Stenzel, Polym. Chem., 2018, 9, 259
    DOI: 10.1039/C7PY01603D

Search articles by author

Spotlight

Advertisements