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Issue 3, 2018
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Hydrolysis resistant functional polypeptide scaffold for biomaterials

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Abstract

For biomaterials, rich functionality often comes at a cost of precise control over structure. In this paper, we have developed a hydrolysis resistant polypeptide that marries the potential for expansive modification with synthetic control. This polymer, poly(γ-propargyl-L-glutamine) may be prepared from commercially available or previously synthesized poly(L-glutamate) by routine amide bond coupling reactions on a multi gram scale. Afterwards, the polymer may be altered to suit many applications through modification of the side chains or end group by orthogonal and quantitative reactions. The ease of synthesis and versatile nature of poly(γ-propargyl-L-glutamine) makes it a unique and ideal scaffold for biomaterial applications.

Graphical abstract: Hydrolysis resistant functional polypeptide scaffold for biomaterials

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Publication details

The article was received on 15 Sep 2017, accepted on 29 Nov 2017 and first published on 21 Dec 2017


Article type: Paper
DOI: 10.1039/C7PY01586K
Citation: Polym. Chem., 2018,9, 346-351
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    Hydrolysis resistant functional polypeptide scaffold for biomaterials

    W. Wang and P. T. Hammond, Polym. Chem., 2018, 9, 346
    DOI: 10.1039/C7PY01586K

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