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Visible-light activated photoCORMs: Rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

Abstract

Most molecules releasing carbon monoxide by the action of light known up to date are based on carbonyl complexes of metals. They, however, suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light absorbing CO releasing molecules (photoCORMs) is described with mechanistic details on several structural motifs. The possibilities of this development are not exhausted and here we discuss design of new biologically interesting candidates.

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Publication details

The article was received on 03 Mar 2018, accepted on 02 May 2018 and first published on 03 May 2018


Article type: Perspective
DOI: 10.1039/C8PP00096D
Citation: Photochem. Photobiol. Sci., 2018, Accepted Manuscript
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    Visible-light activated photoCORMs: Rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

    P. Sebej and T. Slanina, Photochem. Photobiol. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8PP00096D

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