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Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

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Abstract

The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER− and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

Graphical abstract: Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

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Publication details

The article was received on 08 Feb 2018, accepted on 30 Mar 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C8PP00060C
Citation: Photochem. Photobiol. Sci., 2018, Advance Article
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    Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

    H. Savoie, C. Figliola, E. Marchal, B. W. Crabbe, G. L. Hallett-Tapley, R. W. Boyle and A. Thompson, Photochem. Photobiol. Sci., 2018, Advance Article , DOI: 10.1039/C8PP00060C

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