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Issue 3, 2018
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Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates

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Abstract

Gold nanoparticles (AuNPs; ca. 4 nm) were synthesised and functionalised with a mixed monolayer of polyethylene glycol (PEG) and one of two zinc phthalocyanines (ZnPcs), the difference between the two molecules was the length of the carbon chain that connects the Pc to the gold core. The chain was composed of either three (C3Pc) or eleven (C11Pc) carbon atoms. The C11Pc photosensitiser displayed higher fluorescence emission intensity than the C3Pc in solution. By contrast, the C3Pc photosensitiser exhibited higher fluorescence when bound to the surface of the AuNPs than the C11Pc, despite the shorter carbon chain which was expected to quench the fluorescence. In addition, the C3Pc nanoparticle conjugates exhibited an enhancement in the production of singlet oxygen (1O2). The metal-enhanced 1O2 production led to a remarkable photodynamic efficacy for the treatment of human breast cancer cells.

Graphical abstract: Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates

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Publication details

The article was received on 16 Jun 2017, accepted on 11 Dec 2017 and first published on 21 Dec 2017


Article type: Paper
DOI: 10.1039/C7PP00225D
Citation: Photochem. Photobiol. Sci., 2018,17, 281-289
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    Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates

    P. García Calavia, M. J. Marín, I. Chambrier, M. J. Cook and D. A. Russell, Photochem. Photobiol. Sci., 2018, 17, 281
    DOI: 10.1039/C7PP00225D

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