Issue 40, 2018

Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Abstract

Cp*Co(III)-catalysed selective alkylation of directed C–H bonds of arenes and heteroarenes has been accomplished employing donor–acceptor carbenes, derived from α-diazocarbonyl compounds. The developed method allows ready access to various substituted α-(hetero)aryl-α-arylacetic acid derivatives in good to excellent yields. Synthetic utility was also shown through the synthesis of a substituted indole derivative, an anticancer agent.

Graphical abstract: Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
28 Aug 2018
Accepted
21 Sep 2018
First published
21 Sep 2018

Org. Biomol. Chem., 2018,16, 7346-7350

Cp*Co(III)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

J. Ghorai, M. Chaitanya and P. Anbarasan, Org. Biomol. Chem., 2018, 16, 7346 DOI: 10.1039/C8OB02111B

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