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Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

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Abstract

To develop a photoactivatable bioluminescence imaging technique, a set of high and efficient photoactivatable substrates for Renilla luciferase has been well designed and synthesized. Surprisingly, all of them could release the free luciferin that presented robust bioluminescent signals ex vivo and in living animals after UV irradiation at 365 nm.

Graphical abstract: Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

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Publication details

The article was received on 21 May 2018, accepted on 13 Jun 2018 and first published on 13 Jun 2018


Article type: Communication
DOI: 10.1039/C8OB01192C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

    C. Zhang, L. Cheng, G. Dong, G. Han, X. Yang, C. Tang, X. Li, Y. Zhou, L. Du and M. Li, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01192C

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