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Issue 26, 2018
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Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

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Abstract

A nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) using aminoacetonitrile as the cyanating agent is described. This catalytic system delivered the desired products in moderate to good yields with good substrate compatibility. The readily available starting materials, cost-effective nickel catalyst and metal-free cyanating agent are the major features of the present method.

Graphical abstract: Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

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Publication details

The article was received on 03 May 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01034J
Citation: Org. Biomol. Chem., 2018,16, 4816-4820
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    Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

    L. Wang, Y. Wang, J. Shen, Q. Chen and M. He, Org. Biomol. Chem., 2018, 16, 4816
    DOI: 10.1039/C8OB01034J

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