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Issue 23, 2018
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Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

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Abstract

The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2-a]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal- and base-free conditions. Besides arylacetaldehydes, aliphatic aldehydes were also compatible with this system to deliver the alkyl-substituted imidazo[1,2-a]pyridines in excellent yields with the capability of gram-scale synthesis.

Graphical abstract: Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

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Publication details

The article was received on 26 Apr 2018, accepted on 16 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8OB00981C
Citation: Org. Biomol. Chem., 2018,16, 4227-4230
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    Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

    J. Tan, P. Ni, H. Huang and G. Deng, Org. Biomol. Chem., 2018, 16, 4227
    DOI: 10.1039/C8OB00981C

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