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Catalytic Alkylation Reactions of Weakly Acidic Carbonyl and Related Compounds Using Alkenes as Electrophiles

Abstract

Catalytic alkylation reactions of weakly acidic carbonyl and related pronucleophiles such as amides, esters, and sulfonamides with substituted alkenes are reported. In the presence of a strong Brønsted base catalyst system, potassium hexamethyldisilazide and 18-crown-10 ether, the desired reactions proceeded in high yields at ambient temperature with wide substrate scope. These are atom-economical catalytic alkylation reactions of carbonyl and related compounds.

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Publication details

The article was received on 21 Apr 2018, accepted on 08 Jun 2018 and first published on 08 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB00941D
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Catalytic Alkylation Reactions of Weakly Acidic Carbonyl and Related Compounds Using Alkenes as Electrophiles

    Y. Yamashita, R. Igarasgi, H. Suzuki and S. Kobayashi, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00941D

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