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Issue 22, 2018
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A convergent strategy towards febrifugine and related compounds

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Abstract

We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.

Graphical abstract: A convergent strategy towards febrifugine and related compounds

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Publication details

The article was received on 20 Apr 2018, accepted on 15 May 2018 and first published on 15 May 2018


Article type: Paper
DOI: 10.1039/C8OB00935J
Citation: Org. Biomol. Chem., 2018,16, 4159-4169
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    A convergent strategy towards febrifugine and related compounds

    T. M. M. Maiden, N. Mbelesi, P. A. Procopiou, S. Swanson and J. P. A. Harrity, Org. Biomol. Chem., 2018, 16, 4159
    DOI: 10.1039/C8OB00935J

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