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Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S-S and S-P(O) Bond

Abstract

A Fe(Pc)-catalyzed aerobic oxidation of thiols for the synthesis of disulfide has been developed under mild reaction conditions. In addition, aerobic oxidative cross-dehydrogenative coupling (CDC) reaction of thiols with P(O)-H compounds (H-phosphonates and H-phosphine oxide) for the formation of S-P(O) bond has been demonstrated under the Fe(Pc) catalysis system with a base additive. Control experiments revealed that the use of base (DIPA) in this system controls the synthetic pathways in which thiophosphates are formed.

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Publication details

The article was received on 17 Apr 2018, accepted on 17 May 2018 and first published on 17 May 2018


Article type: Communication
DOI: 10.1039/C8OB00908B
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S-S and S-P(O) Bond

    H. Huang, J. Ash and J. Y. Kang, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00908B

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