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Issue 22, 2018
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Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature

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Abstract

A protocol for the chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder under an oxygen atmosphere is reported. This reaction proceeds efficiently to afford fully substituted unsymmetrical N-arylation phosphinamides at room temperature in excellent yields. Diverse unstable functional groups on the benzene ring of aryl boronic acids such as vinyl, formyl, acetyl, sulfonyl, acetylamino, cyano, nitro, and trifluoromethyl can be accommodated.

Graphical abstract: Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature

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Publication details

The article was received on 17 Apr 2018, accepted on 08 May 2018 and first published on 10 May 2018


Article type: Communication
DOI: 10.1039/C8OB00907D
Citation: Org. Biomol. Chem., 2018,16, 4065-4070
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    Chelation-assisted C–N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature

    Y. Peng, J. Lei, R. Qiu, L. Peng, C. Au and S. Yin, Org. Biomol. Chem., 2018, 16, 4065
    DOI: 10.1039/C8OB00907D

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