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Anti-Staphylococcal Biofilm Activity of Miconazoctylium Bromide

Abstract

We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the matrix biofilm, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.

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Publication details

The article was received on 16 Apr 2018, accepted on 16 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8OB00897C
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Anti-Staphylococcal Biofilm Activity of Miconazoctylium Bromide

    J. Tessier, M. Golmohamadi, K. J. Wilkinson and A. R. Schmitzer, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00897C

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