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Issue 22, 2018
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Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

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Abstract

An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.

Graphical abstract: Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

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Publication details

The article was received on 16 Apr 2018, accepted on 07 May 2018 and first published on 07 May 2018


Article type: Communication
DOI: 10.1039/C8OB00890F
Citation: Org. Biomol. Chem., 2018,16, 4061-4064
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    Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

    M. Jbara, E. Eid and A. Brik, Org. Biomol. Chem., 2018, 16, 4061
    DOI: 10.1039/C8OB00890F

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