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Issue 21, 2018
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Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

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Abstract

A novel protocol for the synthesis of C5-alkylated indole derivatives via a gold-catalyzed reaction of indolines with diazo compounds and subsequent oxidative aromatization has been developed. C–H bond functionalization selectively occurs at the C5-position of indolines without a directing group. The experimental operation is simple and the whole process can be manipulated in one-pot.

Graphical abstract: Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

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Publication details

The article was received on 08 Apr 2018, accepted on 02 May 2018 and first published on 02 May 2018


Article type: Communication
DOI: 10.1039/C8OB00826D
Citation: Org. Biomol. Chem., 2018,16, 3889-3892
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    Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

    W. Zhang, G. Xu, L. Qiu and J. Sun, Org. Biomol. Chem., 2018, 16, 3889
    DOI: 10.1039/C8OB00826D

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