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Issue 20, 2018
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Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

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Abstract

Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid. A broad range of indoles were transformed into the corresponding 3-formylindoles in moderate to good yields and excellent functional group tolerance. Notably, no N-formylation product was detected under our conditions.

Graphical abstract: Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

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Publication details

The article was received on 05 Apr 2018, accepted on 28 Apr 2018 and first published on 30 Apr 2018


Article type: Communication
DOI: 10.1039/C8OB00810H
Citation: Org. Biomol. Chem., 2018,16, 3707-3710
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    Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

    Z. Yin, Z. Wang and X. Wu, Org. Biomol. Chem., 2018, 16, 3707
    DOI: 10.1039/C8OB00810H

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