Issue 26, 2018

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Abstract

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. Its unique structure and bioactivity have drawn vast interest from chemists and biologists, and numerous isolation and bioactivity studies on this molecule have been performed. Recently, its biosynthetic enzymes were identified, and some of their crystal structures were reported. In this review, we describe the isolation of teleocidin derivatives, biosynthetic studies, and detailed analyses of biosynthetic enzymes, to clarify their biosynthetic reactions toward the enzymatic synthesis of bioactive teleocidin compounds.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Article information

Article type
Review Article
Submitted
05 Apr 2018
Accepted
14 May 2018
First published
14 May 2018

Org. Biomol. Chem., 2018,16, 4746-4752

Author version available

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

T. Awakawa and I. Abe, Org. Biomol. Chem., 2018, 16, 4746 DOI: 10.1039/C8OB00803E

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